• Nanosuspensions of poorly water-soluble drugs

    2015-11-30  Nanosuspension could be prepared by precipitation–ultrasonication method. Anti-solvent precipitation is an effect way to make nano-sized particles; ultrasonication could control the process of nucleation and crystallization effectively. Spray drying or freeze drying could make dry nanoparticles that could store a longer time.

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  • Preparation and Characterization of Nanosuspension of ...

    2016-3-16  Methods: The nanosuspension of aprepitant was prepared by HPH and H96 approach. The prepared nanosuspensions were characterized for their particle size and zeta potential. The for DSC, FT-IR, solubility and dissolution. The optimized nanosuspension (NCLH5) prepared using combination of

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  • Preparation, characterization, biodistribution and ...

    2013-10-15  Preparation of HCPT nanosuspensions. HCPT nanosuspensions were prepared by the precipitation–ultrasonication method. Briefly, the HCPT bulk powder was dissolved in DMSO (50 °C) to form an organic solution containing 50 mg/ml of drug. The organic solution was then allowed to cool to room temperature. Fetal calf serum was used as an anti-solvent.

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  • Preparation of parenteral nanocrystal suspensions of ...

    2020-10-22  The ETO NCs were prepared by the method of antisolvent precipitation ... then coated with a 30 nm layer of gold ... L., Xu, Y. Wang, Y. Preparation of fenofibrate nanosuspension and study of its ...

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  • A stable hydrocortisone nanosuspension for improved ...

    2020-1-13  Preparation of nanosuspensions Nanosuspension of HC was prepared through two main steps: the first one involves dispersing the drug in a medium of the stabilizers and second one is particle size reduction in milling chamber. HC (2%, w/v) was added to a solution of 0.1% (w/v) SDS, 0.5%, (w/v) HPMC and 0.2% (w/v) PVP and sonicated for 10min. Drug

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  • Fabrication of Ibrutinib Nanosuspension by Quality by ...

    2019-10-28  Precipitation-ultra sonication method was applied for the preparation of nanosuspension. In brief, the required quantity of IBR (30 mg) was weighed and dissolved in acetone (1.0 mL) which is further added to aqueous stabilizer solution under ultrasonication (10 s on and 5 s off) at an amplitude of 40 W (Sonics Materials, Inc., Vibracell VCX ...

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  • Nasal delivery of nanosuspension-based

    2020-4-15  Preparation of LOR nanosuspension. The Precipitation-ultrasonication method was used to prepare the LNS as a pre-dispersion (Alshweiat et al., 2018). LOR was dissolved in ethanol (200 mg mL −1) as a solvent phase, and F68 was dissolved in water (pH 5.7) as an antisolvent phase (0.2%, w/v). Both solvent and antisolvent phases were filtered through a 0.45 μm filter (FilterBio PES Syringe

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  • Preparation, characterization and pharmacokinetics of ...

    2017-5-23  In the present study, cyadox (Cyx) nanosuspension was successfully prepared by recrystallization based on acid–base neutralization combined with high pressure homogenization method

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  • Preparation, characterization, and evaluation of ...

    2018-4-18  Preparation of azoxystrobin nanosuspension. Azoxystrobin nanosuspension was manufactured by wet media milling. In brief, azoxystrobin powder was dispersed in an aqueous solution containing one of the six surfactants (SDS, PVP K30, F68,

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  • A simple improved desolvation method for the rapid ...

    2016-10-1  The current study tried to establish a simple and fast method for the preparation of BSA and HSA nanoparticles, based on an improved desolvation procedure under the aspect of a controllable particle size around 100 nm for drug delivery applications. The Procedure used for the nanoparticles preparation was simplified by using a designed apparatus for controlling the addition of ethanol and it was used instead of conventional tubing pump which enabled the preparation

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  • Preparation, Optimization and Evaluation of Intravenous ...

    2015-4-9  Preparation and Optimization of Curcumin Nanosuspensions Curcumin nanosuspension was prepared by solvent-antisolvent precipitation method as described previously [16]. Different compositions were used as shown in Table 1. Two media were used in the preparation

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  • Preparation of parenteral nanocrystal suspensions of ...

    2020-10-22  The ETO NCs were prepared by the method of antisolvent precipitation ... then coated with a 30 nm layer of gold ... L., Xu, Y. Wang, Y. Preparation of fenofibrate nanosuspension and study of its ...

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  • Clarithromycin Dissolution Enhancement by Preparation

    2018-7-10  The precipitation was performed in 100% Based on technical aspect, another outstanding feature of nanosuspensions is diversity of methods used for preparation. Generally, the existing processes for producing nanosuspension can be classified into top-down and bottom-up processes. The top-down process involves comminution

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  • Preparation, characterization and antitumor activity ...

    nanosuspension using a rotary evaporator R201BL (SENCO, Shanghai,China)at55 C,andthenacertainamountofHP-b-CD were added into the nanosuspension and mixed evenly, nally the SLB nanoparticles was obtained by the lyophilizer at 68 C for 64 h. The preparation processes are illustrated in Fig. 2. 2.3. Optimization of the preparation process of SLB

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  • PLGA nanoparticle formulation by different

    2.2. Preparation and optimization of EGCG NS and EGCG-Pip NC Anti-solvent precipitation method was used for the synthesis of different types of nanoformulations which required organic phase and anti-solvent phase. The polymer (zein) and stabi-lizer (lecithin) were dissolved in the 70% (v/v) ethanol which

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  • EFFECT OF DIFFERENT STABILIZERS ON THE

    effect of different stabilizers on the formulation of simvastatin nanosuspension prepared by precipitation ultrasonication technique

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  • Investigation of various practical techniques to enhance ...

    2018-2-2  Preparation and characterization of ezetimibe nanosuspensions Ezetimibe is a lipid lowering agent. PUMchem indicates its molecular formula as C 24 H 21 F 2 NO 3 and molecular weight as 409.42. Ezetimibe nanosuspensions were prepared by a modifi cation of solvent-antisolvent precipitation method as previously described for other drugs. 8 ...

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  • Preparation, characterization, and evaluation of ...

    2018-4-18  Preparation of azoxystrobin nanosuspension. Azoxystrobin nanosuspension was manufactured by wet media milling. In brief, azoxystrobin powder was dispersed in an aqueous solution containing one of the six surfactants (SDS, PVP K30, F68,

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  • Preparation, characterization and pharmacokinetics of ...

    2017-5-23  Preparation of cyadox nanosuspension Cyx nanosuspension was produced by recrystallization based on acid–base neutralization combined high pressure homogenization.

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  • Nanosuspensions: a promising drug delivery strategy ...

    2010-2-18  Do-Hoon Kuk, Eun-Sol Ha, Dong-Hyun Ha, Woo-Yong Sim, Seon-Kwang Lee, Ji-Su Jeong, Jeong-Soo Kim, In-hwan Baek, Heejun Park, Du Hyung Choi, Jin-Wook Yoo, Seong Hoon Jeong, Sung-Joo Hwang, Min-Soo Kim, Development of a Resveratrol Nanosuspension Using the Antisolvent Precipitation Method without Solvent Removal, Based on a Quality by Design (QbD ...

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  • Preparation and Characterization of Nanosuspension of ...

    Preparation and characterization of nanosuspension The particle size of various batches of nanosuspension prepared by HPH perse and H96 process is depicted in Table 2. The stabilizers, Tween 80 and Poloxamer 188 resulted in smaller particle size compared to PVA and SLS. The combination of Tween 80 and Poloxamer 188

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  • D-optimal Design for Preparation and Optimization of

    2016-6-29  Nanosuspensions were prepared using precipitation method and the effects of stabilizer type and content and drug content on the particle size, polydispersity (PDI) and yield of nanosuspensions were investigated. Results: Particle size, PDI and yield of the optimal nanosuspension formulation were 200.9 nm, 0.24 and 99.6%, respectively.

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  • Gold Stabilized by Nanostructured Ceria Supports: Nature ...

    2011-5-23  method of preparation and pretreatment and the metal loading. For instance, Gates and co-workers considered that there is a strong possibility that there are multiple reaction channels for catalysis of CO oxidation by sup-ported gold, involving gold in different oxidation states [3]. For the WGS reaction, isolated gold cations have been

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  • Formulation and evaluation of mucoadhesive buccal films ...

    2018-11-12  nanosuspension. Objective: Formulation and evaluation of nanosuspension incorporated mucoadhesive buccal films of carvedilol for bioavailability enhancement by avoiding first-pass metabolism. Methods: Carvedilol-loaded nanosuspension was prepared by a precipitation–ultrasonication method with varying concentrations of the polymer.

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  • PLGA nanoparticle formulation by different

    2.2. Preparation and optimization of EGCG NS and EGCG-Pip NC Anti-solvent precipitation method was used for the synthesis of different types of nanoformulations which required organic phase and anti-solvent phase. The polymer (zein) and stabi-lizer (lecithin) were dissolved in the 70% (v/v) ethanol which

  • Get Price
  • Investigation of various practical techniques to enhance ...

    2018-2-2  Preparation and characterization of ezetimibe nanosuspensions Ezetimibe is a lipid lowering agent. PUMchem indicates its molecular formula as C 24 H 21 F 2 NO 3 and molecular weight as 409.42. Ezetimibe nanosuspensions were prepared by a modifi cation of solvent-antisolvent precipitation method as previously described for other drugs. 8 ...

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  • Nanosuspensions: a promising drug delivery strategy ...

    2010-2-18  Do-Hoon Kuk, Eun-Sol Ha, Dong-Hyun Ha, Woo-Yong Sim, Seon-Kwang Lee, Ji-Su Jeong, Jeong-Soo Kim, In-hwan Baek, Heejun Park, Du Hyung Choi, Jin-Wook Yoo, Seong Hoon Jeong, Sung-Joo Hwang, Min-Soo Kim, Development of a Resveratrol Nanosuspension Using the Antisolvent Precipitation Method without Solvent Removal, Based on a Quality by Design (QbD ...

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  • FSE–Ag complex NS: preparation and evaluation of ...

    2018-5-22  2.3 Preparation of Ag–SE_NS. Ag–FSE_NS was prepared by the precipitation–ultrasonication technique . Accurately weighed quantity of Ag–FSE (5 mg) was dissolved in DMSO (1 ml). The antisolvent phase (10 ml) was prepared by dispersing the specific quantity of surfactant (SDS) in milli-Q water.

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  • Tailor-made antioxidative nanocrystals: production and in ...

    2019-12-12  The enclosed doctoral research work was performed during the period from October 2010 to July 2013 under the supervision of Prof. Dr. Cornelia M. Keck and co-supervision of Prof. Dr. Rainer H.

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  • Optimization of process parameters for preparation of ...

    2020-7-7  The objective of this study is to optimize the process parameters for preparing polystyrene (PS) PM2.5 particles by supercritical antisolvent (SAS) method. Toluene was selected as the solvent and ...

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